Cyclophosphamide in severe aplastic anemia?
نویسندگان
چکیده
منابع مشابه
Cyclophosphamide in aplastic anemia?
stances, future investigations will help clarify the division of labor among NK-cell subsets. Although further studies are necessary to more fully understand NK-cell responses to target cell recognition, the work by Fauriat et al sheds light on the functional heterogeneity of human CD56bright and CD56dim NK-cell subsets. This study also advances our knowledge on how multiple NK cell–activating ...
متن کاملTotal lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia.
A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibling following this preparative regimen. There were no episodes of graft reject...
متن کاملComplete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation.
Severe aplastic anemia (SAA) can be successfully treated with allogeneic bone marrow transplantation (BMT) or immunosuppressive therapy. However, the majority of patients with SAA are not eligible for BMT because they lack an HLA-identical sibling. Conventional immunosuppressive therapy also has major limitations; many of its remissions are incomplete and relapse or secondary clonal disease is ...
متن کاملCLINICAL TRIALS AND OBSERVATIONS High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up
Severe aplastic anemia (SAA) is a lifethreatening bone marrow failure disorder that can be treated with bone marrow transplantation, immunosuppressive therapy,and high-dose cyclophosphamide. Here, we report long-term follow-up on 67 SAA patients (44 treatment-naiveand23refractory) treated with high-dose cyclophosphamide. At 10 years, the overall actuarial survival was 88%, the response rate was...
متن کاملHigh-dose cyclophosphamide for severe aplastic anemia: long-term follow-up.
Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder that can be treated with bone marrow transplantation, immunosuppressive therapy, and high-dose cyclophosphamide. Here, we report long-term follow-up on 67 SAA patients (44 treatment-naive and 23 refractory) treated with high-dose cyclophosphamide. At 10 years, the overall actuarial survival was 88%, the response rat...
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ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-09-600205